TRANSFUSION TRANSMITTED INFECTIONS (TTIs) AMONG BLOOD DONORS IN THE BLOOD BANK OF A TERTIARY CARE HOSPITAL IN INDIA: A RECORD BASED STUDY

Mohd Zubair Qureshi, Shazia Handoo, Basira Sultan, Ruby Reshi, Musharaf Bashir

Abstract


Objectives: Transfusion Transmitted Infections (TTIs) are infections caused by potential pathogens which are transmitted to the blood recipients through blood transfusion. This study was primarily carried out to detect sero-positivity of the markers of Hepatitis-B virus (HBV), Hepatitis-C virus (HCV), Human immunodeficiency virus (HIV) and Syphilis in the blood donors at a tertiary care hospital in Srinagar, J&K, India over a of 4 years.

Material and Methods: Blood donations over 4 years from Jan.2015 to Dec.2018 were reviewed retrospectively from the records of blood bank for seropositivity for HBV, HCV, HIV and Syphilis.

Results: A total of 31733 blood units were collected out of which 24494 (77.19%) were replacement and 7239 (22.81%) were voluntary. The seroprevalence of HBV, HCV, HIV and Syphilis was 0.22% (72), 0.16% (52), 0.009% (3) and 0.01% (5) respectively. A decreasing trend of all the major TTIs was observed over these years. Prevalence of all the four TTIs was observed highest in replacement donors as compared to voluntary donors.

Conclusion: Seroprevalence of all the TTIs was low as compared to the studies from rest of the country. Extensive donor selection and screening procedures will help in improving blood safety more. Efforts should be made to maximise voluntary donations and minimise replacement donations.


Keywords


Seroprevalence, Hepatitis B virus, Hepatitis C virus, HIV, Syphlis, Blood donor.

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References


Dean CL, Wade J, Roback JD.Transfusion-Transmitted Infections: an update on product screening, diagnostic techniques, and the path ahead. J Clin Microbiol.2018; 56(7): e00352-18.

Ray G.Current scenario of hepatitis B and its treatment in India. J Clin Transl Hepatol. 2017; 5(3): 277-96.

Patel P, Borkowf CB, Brooks JT, Lasry A, Lansky A, Mermin J.Estimating per-act HIV transmission risk: a systematic review. AIDS.2014; 28(10): 1509-19.

Kondareddy S.Seroprevalence of co-infections among blood donors at the blood bank of a tertiary care hospital, in Southern India. J Evid Based Med Healthc. 2018; 5(38): 2723-6.

Bihl F, Castelli D, Marincola F,Dodd RY, Brandr C. Transfusion-transmitted infections. J Transl Med.2007; 5:25. https://doi.org/10.1186/1479-5876-5-25.

Towards 100% Voluntary Blood Donation: A Global Framework for Action. Geneva: World Health Organization; 2010. 2, Voluntary blood donation: foundation of a safe and sufficient blood supply. Available from: https://www.ncbi.nlm.nih.gov/books/NBK305666/

Shanti B,Meena AK, Rupam B, Ramasastry G, Sandip VS.Evaluation of therapeutic plasma exchange in neuroimmunological disorders: A study of 15 cases in Nizam′s Institute of Medical Sciences, Hyderabad. Asian Journal of Transfusion Science. 2010; 4(1): 43-69.

National AIDS Control Organization (NACO) and National Blood Transfusion Council(NBTC), Ministry of Health and Family Welfare, Government of India. www.naco.gov.in

Kotwal U, Doda V, Arora S, Bhardwaj S. Blood donor notification and counselling: Our experience from a tertiary care hospital in India. Asian Journal of Transfusion Science. 2015 ;9(1):18-22.

Scott SR, Wu Z.Risks and challenges of HIV infection transmitted via blood transfusion. Biosafety and Health. 2019; 1(3): 124-8.

Qureshi MZ, Bashir H, Maroof P, Jeelani S, Bhat N, Akhter F. Seropositivity of Hepatitis B virus and Hepatitis C virus among blood donors at a tertiary care hospital in Kashmir: a ten year study. Int J Cur Res Rev.2016;8(19):17-20.

World Health Organization, Representative India. Introducing hepatitis B under universal immunization program frequently asked questions about hepatitis B disease and vaccine.Available at:http://www.whoindia.org/CHS/HepB/FAQ.htm

Handoo S, Ryhan R, Reshi R, Sayeed SI. Seroprevalence of different transfusion transmissible infections among blood donors in a tertiary care hospital of Kashmir: a hospital based sStudy. Int J Med Res Prof.2018;4(2):270-2.

Mitrovic N, Delic D, Markovic-Denic L, Jovicic M, Popovic N, Bojovic K et al. Seroprevalence and risk factors for hepatitis C virus infection among blood donors in Serbia: A multicentre study. Dig Liver Dis. 2015;47(7):572-6.

Mahmood MA, Khawar S, Anjum AH, Ahmad SM, Rafiq S, Nazir I et al. Prevalence of Hepatitis B, C and HIV infection in blood donors of Multan Region. Annals of King Edward Medical Univ.2004;10(4): 459-61.

Chandra T, Rizvi SNF, Agarwal D. Decreasing prevalence of transfusion transmitted infection in Indian scenario. Sci World J.2014.https://doi.org/10.1155/2014/173939

Paul R, Kar S, Zaman FA, Pal S. The quest for an Indian blood law as of blood transfusion services regulatory framework. Asian J Tranfus Sci. 2011; 5(2): 171-4.

Mandal R, Mondal K.Transfusion transmissible infections among blood donors from a sub-Himalayan rural tertiary care centre in Darjeeling, India. J Tradit Complement Med. 2016; 6(3): 224-9.




DOI: http://dx.doi.org/10.24125/sanamed.v15i3.445

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