FROM DERMATITIS TO CENTRAL DIABETES INSIPIDUS

Jasmina Skoric, Bojan Pavkovic, Ivana Medic

Abstract


The case report shows a seven-month-old, female infant whose malignancy initially manifested as a seemingly harmless skin condition such as dermatitis. When the patient was three months old, the first symptoms were identified such as atopic and intertriginous dermatitis and milliaria. After a few months, a tumefaction appeared on the neck, behind the left ear, which was treated as an abscess. As the prescribed antibiotic therapy showed no results, the patient underwent a surgical procedure followed by a pathohistological treatment of the lesional tissue suggestive of histiocytosis. The patient was subjected to chemotherapy for a duration of one year. However, one year after the end of the treatment, a recurrence was found, which required an additional, yet successful chemotherapy treatment. As an adverse sequelae, central diabetes insipidus was confirmed.


Keywords


malignancy, dermatitis, tumefaction, chemotherapy, abscess, recurrence

Full Text:

PDF

References


Arico M, Clementi R, Caselli D, Danesino C. Histiocytic disorders. Hematol J. 2003; 4(3):171-9.

Lipton JM, Arceci RJ. Histocyte disorders.In: Hoffman R, editor. Hematology. Basic principles and practice, 5th ed. Philadelphia: Churchill Livingstone, an imprint of Elsevier Inc; 2008: Chap. 52.

Janka GE. Hemophagocytic syndromes. Blood Rev. 2007; 21(5): 245-53.

Brook CDG, Clayton P, Brown R, editors. Brooks clinical pediatric endocrinology. 6th ed. Oxford: Wiley-Blackwell; 2009.

Lifshitz F, editor. Pediatric endocrinology. 5th ed. New York: Informa Healthcare USA Inc, 2007.

Janka G, zur Stadt U. Familial and acquired hemophagocytic lymphohistiocytosis. Hematology Am Soc Hematol Educ Program.2005; 2005: (1): 82–8.

National Institute for Clinical Excellence. Guidance on the use of human growth hormone (somatotropin) in children with growth failure. Tecnology Appraisal Guidance.2010. https://www.nice.org.uk/guidance/ta188

Zdravković D. Klinička pedijatrijska endokrinologija. Beograd: Zavod za udžbenike i nastavna sredstva; 2001.

Khung S, Budzik J.F, Amzallag – Bellenger E, Lambiliote A, Soto Ares G, Cotton A. et al. Skeletal involvement in Langerhans cell histiocytosis. Insights Imaging 2013; 4(5): 569-79.

Haupt R, Minkov M, Astigarraga I, Schafer E, Nanduri V, Jubran R et al. Euro Histio Network. Langerhans cell histiocytosis (LCH): Guidellines for diagnosis, clinical work-up, and treatment for patients till the age of 18 years. Pediatric Blood Cancer 2013; 60(2): 175-84.

Radlović N, Bogdanović R. Pedijatrija. Beograd: Akademska misao; 2016.

Verbski JW, Grossman WJ. Hemophagocytic lymphohistiocytosis: Diagnosis, pathophysiology, treatment, and future perspectives. Ann Medd. 2016; 47(1): 56-72.




DOI: http://dx.doi.org/10.24125/sanamed.v15i1.389

Refbacks

  • There are currently no refbacks.


Copyright (c) 2020 Jasmina Skoric, Bojan Pavković, Ivana Medić

Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 International License.