IS PREDICTION OF RENAL FAILURE WITH ITS INDICES FEASIBLE WITH PRESENCE OF HISTOPATHOLOGIC EVIDENCE FOR GASTRIC INTESTINAL METAPLASIA ?
Objectives: Gastric intestinal metaplasia have traditionally been associated with gastric adenocarcinoma. Gastric intestinal metaplasia is usually related to the Helicobacter pylori infection, older ages, smoking history, consumption of strong spicy foods, socioeconomic status and presence of IL10-592 C/A. The purpose of the present research study was to evaluate the simple laboratory parameters in subjects with gastric intestinal metaplasia
Findings: From May 2018 and October 2018, a total of 541, 281 male and 260 female, consecutive cases with gastric intestinal metaplasia with the mean age of 58.5±15 years had been enrolled retrospectively with exclusion of the cases with a severe underlying disease, including a gastric cancer and gastric resection. The gastroscopy with the antral biopsy had been performed for all the cases and the biopsy samples had been evaluated for the presence of gastric intestinal metaplasia by Hematoxylin and Eosin and Helicobacter pylori status by Giemsa.The chi-squared test and independent t test were used for comparison. The mean serum urea level detected as 34.2.±16.1 mg/dL in the gastric intestinal metaplasia and 31.2±13.1 mg/dL in the control (95% CI from 32,3 to 34,6; p=0.013), while the mean serum creatinin level 0.84±0.28 mg/dL in the gastric intestinal metaplasia and 0.80±0.26 mg/dL in the control (95% CI from 0,80 to 0,85; p=0.042). Gastric intestinal metaplasia was detected mostly in elderly and male, regarding the multiple logistic regression (p<0.001).
Conclusion: The serum urea and creatinin levels may serve as a simple clinical tool to predict the cases patients at risk for gastric intestinal metaplasia.
Giroux V, Rustgi AK. Metaplasia: tissue injury adaptation and a precursor to the dysplasia-cancer sequence. Nat Rev Cancer. 2017;17(10):594-604.
Rugge M, Sugano K, Scarpignato C, Sacchi D, Oblitas WJ, Naccarato AG. Gastric cancer prevention targeted on risk assessment: Gastritis OLGA staging. Helicobacter. 2019 Feb17:e12571. doi: 10.1111/hel.12571. [Epubahead of print]
Kim N, Park YS, Cho SI, Lee HS. Prevalence and risk factors of atrophic gastritis and intestinal metaplasia in a Korean population without significant gastroduodenal disease. Helicobacter. 2008;13(4):245-55.
Sengul D, Sengul I. Frequency of Helicobacter Pylori and Association of Location, Six Age Groups, and Assessment of Borderline of 50-year Base-age, Based on the Anatomic Pilot Region with the Degree of Helicobacter Pylori Colonization. BakirkoyMed J. 2018; 14(4):381-8.
Kocazeybek B, Tokman HB. Prevalence of primary antimicrobial resistance of Helicobacter pylori in Turkey: a systematic review. Helicobacter. 2016;21(4):251-60.
Esen R, Dulger AC, Begenik H, Demirtas L, Ebinc S, Aytemiz E, et al. Prevalence of Helicobacter pylori in patients with Brucellosis. J Investig Med. 2012; 60(6):895-7.
Demir T, Turan M, Tekin A. Helicobacter pylori antigen prevalance in dispeptic patients in Kirsehir region. Dicle Tıp Derg. 2011;38(1):44-8.
Li D, Bautista MC, Jiang SF, Daryani P, Brackett M, Armstrong MA, et al. Risks and predictors of gastric adenocarcinoma in patients with gastric intestinal metaplasia and dysplasia: a population-based study. Am J Gastroenterol. 2016;111(8):1104-13.
Kim GH, Liang PS, Bang SJ, Hwang JH. Screening and surveillance for gastric cancer in the United States: Is it needed? GastrointestEndosc. 2016;84(1):18-28.
Shao L, Li P, Ye J, Chen J, Han Y, Cai J, et al. Risk of gastric cancer among patients with gastric intestinal metaplasia. Int J Cancer. 2018 Apr 29. doi: 10.1002/ijc.31571. [Epubahead of print].
Reddy KM, Chang JI, Shi JM, Wu BU. Risk of gastric cancer among patients with intestinal metaplasia of the stomach in a US integrated health care system. Clin Gastroenterol Hepatol. 2016;14(10):1420-5.
World Cancer Research Fund International. Diet, nutrition, physical activity and stomach cancer. CUP: Continuous Update Project. http://www.wcrf.org/sites/default/files/Stomach-Cancer-2016-Report.pdf. AccessedAugust 24, 2018.
Shousha S, Keen C, Parkins RA. Gastric metaplasia and Campylobacter pylori infection of duodenum in patients with chronic renal failure. J Clin Pathol. 1989;42(4):348-51.
Homse Netto JP, Pinheiro JPS, Ferrari ML, Soares MT, Silveira RAG, Maioli ME, et al. Upper gastrointestinal alterations in kidney transplant candidates. J Bras Nefrol. 2018; 40(3):266-72.
Misra V, Misra SP, Shukla SK, Jaiswal PK, Agarwal R, Tondon S. Endoscopic and histological changes in upper gastrointestinal tract of patients with chronic renal failure. Indian J Pathol Microbiol. 2004;47(2):170-3.
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