SALIVA AS A DIAGNOSTIC FLUID
Saliva is a readily available oral fluid with many functions, from digestion, maintenance of oral tissues' integrity, to caries prevention. Changes regarding its secretion may be divided into qualitative and quantitative: both of them are a consequence of certain conditions/diseases (e.g. internal factors) or nutrients/drugs ingested (e.g. external factors). During the last 15 years, technological advances gave a significant momentum to utilization of saliva as a diagnostic tool. Analysis of saliva, just like the blood analysis, has two main objectives: to identify the subjects suffering from a certain disorder, and to follow the development and progress of therapy. This paper provides an overview of possibilities for the use of saliva for diagnostic purposes and gives specific examples of some clinical investigations, with the final aim to stimulate the use of this noninvasive means for the health care promotion.
Farnaud SJ, Kosti O, Getting SJ, Renshaw D. Saliva: physiology and diagnostic potential in health and disease. ScientificWorldJournal. 2010; 10: 434-56.
Malamud D, Tabak LA, editors. Saliva as a Diagnostic Fluid: Ann NYAcad Sci. 1992. Malamud D, Tabak LA, eds. Saliva as a Diagnostic Fluid; No. 694.
Malamud D, Niedbala RS. Oral-based diagnostics. 1st ed. Boston: Mass; 2007.
Corstjens PLAMMD. Point-of-care Diagnostics for infectious diseases. In: Wong DT, editor. Saliva Diagnostics. Ames: Wiley-Blackwell; 2008. p. 243-54.
Wen ZT, Yates D, Ahn SJ, Burne RA. Biofilm formation and virulence expression by Streptococcus mutans are altered when grown in dual-species model. BMC Microbiol. 2010; 10: 111.
Goncalves Lda R, Soares MR, Nogueira FC, et al. Comparative proteomic analysis of whole saliva from chronic periodontitis patients. J Proteomics. 2010;73 (7): 1334-41.
Parisi MR, Soldini L, Di Perri G, Tiberi S, Lazzarin A, Lillo FB.Offer of rapid testing and alternative biological samples as practical tools to implement HIV screening programs. New Microbiol. 2009; 32(4): 391-6.
White DA, Scribner AN, Huang JV. A comparison of patient acceptance of fingerstick whole blood and oral fluid rapid HIV screening in an emergency department. J Acquir Immune Defic Syndr. 2009; 52(1): 75-8.
Arregger AL, Cardoso EM, Tumilasci O, Contreras LN. Diagnostic value of salivary cortisol in end stage renal disease. Steroids. 2008; 73(1): 77-82.
Nagler RM. Saliva analysis for monitoring dialysis and renal function. Clin Chem. 2008; 54(9): 1415-7.
Savica V, Calo L, Santoro D, Monardo P, Granata A, Bellinghieri G. Salivary phosphate secretion in chronic kidney disease. J Ren Nutr. 2008; 18(1): 87-90.
Bilodeau E, Alawi F, Costello BJ, Prasad JL. Molecular diagnostics for head and neck pathology. Oral Maxillofac Surg Clin North Am. 2010; 22(1): 183-94.
Hu S, Arellano M, Boontheung P, et al. Salivary proteomics for oral cancer biomarker discovery. Clin Cancer Res. 2008; 14(19): 6246-52.
Navazesh M. Methods for collecting saliva. Ann NY Acad Sci. 1993; 694: 72-7.
Kaufman E, Lamster IB The diagnostic applications of saliva-a review. Crit Rev Oral Biol Med. 2002; 13(2): 197-212.
Tavassoli M, Brunel N, Maher R, Johnson NW, Soussi T. P53 antibodies in the saliva of patients with squamous cell carcinoma of the oral cavity. Int J Cancer. 1998; 78(3): 390-1.
Rhodus NL, Dahmer L, Lindermann K, Rudney J, Mathur A, Bereuter J. s-IgA and cytokine levels in whole saliva of Sjogren’s syndrome patients before and after oral pilocarpine hydrochloride administration: a pilot study. Clin Oral Investig. 1998; 2(4): 191-6.
Black KP, MerillKW, Jackson S, Katz J. Cytokine profiles in parotid saliva from HIV-1 infected individuales: changes associated with opportunistic infections in the oral cavity. Oral Microbiol Immunol. 2000; 15(2): 74-81.
Brozovic S,Vucicevic-Boras V, Mravak-Stipetic M, Jukic S, Kleinheinz J, Lukac J. Salivary levels of vascular endothelial growth factor(VGEF) in recurrent aphthous ulceration. J Oral Pathol Med. 2002; 31(2): 106-8.
Pezelj-Ribaric S, Prso IB, Abram M, Glazar I, Brumini G, Simunovic-Soskic M. Salivary levels of tumor necros factor- alpha in oral lihen planus. Mediators Inflamm. 2004; 13(2): 131-3.
Simcic D, Pezelj-Ribaric S, Grzic R, Horvat J, Brumini G, Muhvic-Urek M. Detection of salivary interleukin 2 and interleukin 6 in patients with burning mouth syndrome. Mediators Inflamm. 2006; 2006(1): 54632.
Pezelj-Ribaric S, Kqiku L, Brumini G, et al. Proinflammatory cytokine levels in saliva in patients with burning mouth syndrome before and after treatment with low level laser therapy. Lasers Med Sci. 2013; 28(1): 297-301.
Pezelj-Ribaric S, Prpic J, Miletic I, Brumini G, Soskic MS, Anic I. Association between oral lichenoid reactions and amalgam restorations. J Eur Acad Dermatol Venereol. 2008; 22(10): 1163-7.
Simunovic Soskic M, Pezelj-Ribaric S, Brumini G, Glazar I, Grzic R, Miletic I. Salivary levels of TNF-alpha and IL-6 in patents with denture stomatitis before and after low-level laser therapy. Photomed Laser Surg. 2010; 28(2): 189-93.
- There are currently no refbacks.
Copyright (c) 2016 SANAMED
This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.