SECONDARY ANTIPHOSPHOLIPID SYNDROME REVEALED BY THE SUDDEN ONSET OF PNEUMONIA-CASE REPORT
Introduction: Secondary antiphospholipid syndrome (SAPS) ia APS that occurs in the context of another medical condition. Althgough antiphospholipid antibodies (aPL) can occur in patients with viral, bacterial or protozoal infections, they are rarely associated with thrombosis.
Aim: To present an uncommon case of pneumonia and pleural effusion complicated with pulmonary thromboembolism in a patient with systemic lupus erythematosus (SLE), due to non-diagnosed secondary antiphospholipid syndrome.
Miyakis S, Lockshin MD, Atsumi T, Branch DW, Brey RL, Cervera R et al. International consensus statement on an update of the classification criteria for definite antiphospholipid syndrome (APS). J Thromb Haemost. 2006; 4(2):295–306.
Radin M, Sciascia S, Erkan D, Pengo V, Tektonidou MG, Ugarte A, et al. The adjusted global antiphospholipid syndrome score (aGAPSS) and the risk of recurrent thrombosis: Results from the APS ACTION cohort.Semin Arthritis Rheum. 2019;49(3):464-8.
Lazovic B, Zlatkovic-Svenda M, Jasarovic D, Stevanovic D. Systemic lupus erythematosus presenting as acute lupus pneumonitis.Arch Bronconeumol. 2018; 54(4):222-3.
Maioli G, Calabrese G, Capsoni F, Gerosa M, Meroni PL, Chighizola CB. Lung Disease in antiphospholipid syndrome.Semin Respir Crit Care Med. 2019;40(2):278-94.
Ruffatti A, Del Ross T, Ciprian M, Bertero MT, Sciascia S, Salvatore S, et al. Risk factors for a first thrombotic event in antiphospholipid antibody carriers: a prospective multicentre follow-up study. Ann Rheum Dis. 2011;70(6):1083–6.
Tektonidou MG, Andreoli L, Limper M, Tincani A, Ward MM. Management of thrombotic and obstetric antiphospholipid syndrome: a systematic literature review informing the EULAR recommendations for the management of antiphospholipid syndrome in adults. RMD Open. 2019; 5(1):e000924.
Lim W, Crowther MA, Eikelboom JW. Management of antiphospholipid antibody syndrome: a systematic review. JAMA 2006; 295 (9): 1050- 7.
Kato M, Hisada R, Atsumi T. Clinical profiles and risk assessment in patients with antiphospholipid antibodies. Expert Rev Clin Immunol. 2019;15(1):73-81.
Noureldine MHA, Nour-Eldine W, Khamashta MA, Uthman I.Insights into the diagnosis and pathogenesis of the antiphospholipid syndrome. Semin Arthritis Rheum. 2019; 48(5):860-6.
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