IS THERE ANY LINK BETWEEN A KIND OF THYROCYTE DYSFUNCTION, HYPOTHYROIDISM, AND INFLAMMATORY HEMATOLOGIC PARAMETERS IN THE CASES POSSESSING THE BENIGN THYROID NODULES? A 5-YEAR SINGLE-CENTRE EXPERIENCE
Objective: Microscopically, the thyroid gland is composed of spherical follicles and thyroid parenchyma includes two major cell types, the thyrocytes releasing thyroid hormones and C cells secreting mature calcitonin. Hypothyroidism has been known as being associated with the various abnormalities of the coagulation system. In the present study, it had been purposed to inverstigate the relationship between inflammatory hematological parameters, RBC, Hb, Htc, RDW, WBC, neutrophil, lymhocyte, N/L, Plt, MPV, PCT, PDW and hypothyroid hormonal status in the cases possessing the benign thyroid nodules.
Material and Methods: A total of 313 cases, 202 with hypothyroidism, 111 with euthyroidism possesing the benign thyroid nodules, that was verified with the cytological evaluation after one-endocrine surgeon performed ultrasonography (US) guided fine needle aspiration (FNA) (US-g-FNA), at the Division of Endocrine Surgery, Department of General Surgery, Giresun University Faculty of Medicine, Giresun, Turkey, in conformity with the criteria, were enrolled into the study during the period, from April 2010 to April 2015. The documents that were used to follow consisted of laboratory tests of the cases including both the thyroid hormones, freeT3, FreeT4, and TSH, and the inflammatory hematological parameters were reviewed and scanned retrospectively. The upper limit of the normal Thyrotropin (TSH) reference range was determined as 4 mU/L in the present study.
Results: No statistically significant difference was found between the inflammatory hematological parameters, RBC, Hb, Htc, RDW, WBC, neutrophil, lymhocyte, N/L, Plt, MPV, PCT, PDW, and hypothyroidism (p>0.05).
Conclusion: Inflammatory hematological parameters may not be useful for estimating the hormonal status of the thyroid gland in the cases with the benign thyroid nodules verified with the cytological evaluation, TBSRTC.
Pankow BG, Michalak J, McGee MK. Adult human thyroid weight. Health Phys. 1985;49(6):1097-103.
Hegedüs L. Thyroid size determined by ultrasound. Influence of physiological factors and non-thyroidal disease. Dan Med Bull. 1990;37(3):249–63.
Wartofsky L. The thyroid gland. In: Becker KL (ed) Principles and practice of endocrinology and metabolism. Lippincott Williams & Wilkins, Philedelphia, pp 308-401.
Spencer CA, LoPresti JS, Patel A, Guttler RB, Eigen A, Shen D, et al. Applications of a new chemiluminometric thyrotropin assay to subnormal measurement. J Clin Endocrinol Metab. 1990;70(2):453-60.
Kondalenko VF, Kalinin AP, Odinokova VA. [Ultrastructure of the normal and pathologic human thyroid gland]. Arkh Patol. 1970;32(4):25-34.
Nesland JM, Sobrinho-Simoes M, Johannessen JV. Scanning electron microscopy of the human thyroid gland and its disorders. Scanning Microsc. 1987;1(4):1797-810.
Drews RE. Critical issues in hematology: anemia, thrombocytopenia, coagulopathy, and blood product transfusions in critically ill patients. Clin Chest Med. 2003; 24(4):607-22.
Golde DW, Bersch N, Chopra IJ, Cline MJ. Thyroid hormones stimulate erythropoiesis in vitro. Br J Haematol. 1977; 37(2):173-7.
Kawa MP, Grymula K, Paczkowska E, Baskiewicz-Masiuk M, Dabkowska E, Koziolek M, et al. Clinical relevance of thyroid dysfunction in human haematopoiesis: biochemical and molecular studies. Eur J Endocrinol. 2010;162(2):295-305.
Mackenzie GM. Anemia in hypothyroidism. JAMA. 1926; 86(7):462-64.
Das KC, Mukherjee M, Sarkar TK, Dash RJ, Rastogi GK. Erythropoiesis and erythropoietin in hypo- and hyperthyroidism. J Clin Endocrinol Metab. 1975;40(2):211–20.
Fein HG, Rivlin RS. Anemia in thyroid diseases. Med Clin North Am. 1975;59(5):1133-45.
Surks MI, Hollowell JG. Age-specific distribution of serum thyrotropin and antithyroid antibodies in the US population: implications for the prevalence of subclinical hypothyroidism. J Clin Endocrinol Metab. 2007;92(12):4575-82.
Valdés S, Maldonado-Araque C, Lago-Sampedro A, Lillo-Muñoz JA, Garcia-Fuentes E, Perez-Valero V, et al. Reference values for TSH may be inadequate to define hypothyroidism in persons with morbid obesity: Di@bet.es study. Obesity (Silver Spring). 2017;25(4):788-93.
Cibas ES, Ali SZ. The Bethesda system for reporting thyroid cytopathology. Thyroid. 2009;19(11):1159 -65.
Haugen BR, Alexander EK, Bible KC, Doherty GM, Mandel SJ, Nikiforov YE, et al. 2015 American Thyroid Association Management Guidelines for Adult Patients with Thyroid Nodules and Differentiated Thyroid Cancer: The American Thyroid Association Guidelines Task Force on Thyroid Nodules and Differentiated Thyroid Cancer. Thyroid. 2016 ;26(1):1-133.
American Thyroid Association (ATA) Guidelines Taskforce on Thyroid Nodules and Differentiated Thyroid Cancer, Cooper DS, Doherty GM, Haugen BR, Kloos RT, Lee SL, Mandel SJ, Mazzaferri EL, McIver B, Pacini F, Schlumberger M, Sherman SI, Steward DL, Tuttle RM. Revised American Thyroid Association management guidelines for patients with thyroid nodules and differentiated thyroid cancer. Thyroid 2009;19(11):1167– 214.
Cooper DS, Doherty GM, Haugen BR, Kloos RT, Lee SL, Mandel SJ, et al. Management guidelines for patients with thyroid nodules and differentiated thyroid cancer. Thyroid 2006,16(2):109–42.
Fujita H. Fine structure of the thyroid gland. Int Rev Cytol. 1975;40:197-280.
Yango J, Alexopoulou O, Eeckhoudt S, Hermans C, Daumerie C. Evaluation of the respective influence of thyroid hormones and TSH on blood coagulation parameters after total thyroidectomy. Eur J Endocrinol. 2011;164(4):599-603.
Geetha J, Srikrishna R. Role of red blood cell distribution width (rdw) in thyroid dysfunction. Int J Biol Med Res. 2012;3(2):1476–8.
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